Devices to overcome thebuccalmucosal barrier to administer therapeuticpeptides The advent of buccal peptides represents a significant leap forward in therapeutic delivery, offering a promising alternative to traditional injection-based methods and challenging the limitations of conventional oral peptide formulations.作者：KJ Colston·2025·被引用次数：3—Oral peptidedrug formulations are highly desirable because they offer enhanced patient compliance compared to subcutaneous injections, while ... By leveraging the unique anatomical and physiological characteristics of the buccal mucosa, researchers and companies are developing innovative ways to administer peptide-based drugs directly into the bloodstream, bypassing the digestive system's harsh environment and improving patient compliance. This approach aims to unlock the full potential of peptides as a major class of future therapeutics, enhancing their bioavailability and efficacy.作者：AA Amer·2025—Theoralcavity, comprising thebuccaland sublingual mucosa, offers a promising alternative forpeptidedelivery. Its rich vascularization allows for rapid ...
Peptides, complex molecules essential for numerous bodily functions, have long held therapeutic promiseDrug Delivery of Peptides: The Buccal Route | SpringerLink. However, their inherent instability and poor absorption when taken orally have historically necessitated invasive injection routes.The aim ofBuccal-PEP is to develop next generationbuccalpatches to deliver thepeptide-analogues to the blood via thebuccalcavity. The proposed structures ... The buccal route, referring to delivery within the oral cavity (the cheek lining), offers a compelling solution. The buccal mucosa is highly vascularized, allowing for rapid absorption of substances directly into systemic circulation, similar to sublingual delivery作者：MA Karsdal·2015·被引用次数：67—This paper reviews the most advancedoralformulation technologies, and highlights key lessons and implications from studies undertaken to date with theseoral.... This bypasses the gastrointestinal tract, avoiding degradation by digestive enzymes and interactions with food, thereby overcoming a major hurdle in oral peptide drug development.
Significant research and development are focused on creating effective delivery systems for buccal peptides. These innovations aim to overcome the natural barriers of the buccal mucosa and ensure efficient absorptionDevices to overcome the buccal mucosal barrier ....
* Biomaterial Patches: Companies like BUCCAL-PEP are developing advanced biomaterial patches designed for in-cheek delivery. These patches are engineered to adhere to the buccal lining and release peptide analogues in a controlled manner, addressing bioavailability and precise dosage challengesMaterials for oral delivery of proteins and peptides.
* Nanotechnology: Nanoparticles are emerging as a key technology for enhancing the oral and buccal delivery of peptidesA patch for buccal (cheek) administration of peptides. These tiny carriers can protect peptides from degradation and facilitate their passage through the mucosal barrier.
* Device-Assisted Delivery: Researchers are exploring devices that can help overcome the buccal mucosal barrier. These might involve non-invasive methods like stretching the buccal mucosa to temporarily increase permeability, thereby boosting drug absorption.Materials for oral delivery of proteins and peptides
* Polymeric Films: Advanced formulations, such as layer-by-layer polymeric films, are being investigated for buccal GLP-1 delivery, aiming to enhance peptide penetration while minimizing tissue stressBuccal delivery for peptide drugs.
The shift towards buccal peptide delivery offers several key advantages that could transform patient care:
* Improved Patient Compliance: Eliminating the need for injections significantly enhances patient comfort and adherence to treatment regimens, especially for chronic conditions.作者：MA Karsdal·2015·被引用次数：67—This paper reviews the most advancedoralformulation technologies, and highlights key lessons and implications from studies undertaken to date with theseoral...
* Enhanced Bioavailability: By bypassing the gastrointestinal tract, buccal delivery protects peptides from enzymatic degradation and improves the amount of active drug that reaches the bloodstream2025年7月22日—...oral peptideformulations are ... Buccal administration of peptides is a potential alternative to injections and oral formulations..
* Rapid Onset of Action: Direct absorption into the bloodstream can lead to a quicker therapeutic effect compared to oral pills that must first pass through the digestive system.
* Reduced Side Effects: Avoiding the gut may also reduce certain gastrointestinal side effects commonly associated with oral peptide medications.
The development of buccal peptides is part of a broader movement towards more convenient and effective peptide-based therapies. While challenges remain in optimizing delivery systems and ensuring long-term stability, the progress made in overcoming the limitations of oral and injectable peptides is substantial. As research continues, buccal delivery systems are poised to play a crucial role in making peptide therapeutics more accessible and impactful, potentially revolutionizing treatments across various medical fields, from endocrinology and orthopaedics to broader wellness applications.
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