Adaptivepeptidedispersions enable drying-induced biomoleculeencapsulation Peptide encapsulation is a critical strategy for improving the stability, bioactivity, and delivery of peptides, which are short chains of amino acids essential for numerous biological functions. By enclosing peptides within protective matrices, researchers and formulators can overcome challenges such as degradation by enzymes, poor oral bioavailability, and undesirable sensory properties作者：A Mohan·2015·被引用次数：272—Proteins, polysaccharides and lipidsare the three carrier systems that have been utilized in food peptide encapsulation.. This process ensures that peptides retain their intended therapeutic or functional effects from production through to their point of application. The effectiveness of peptide encapsulation is well-documented, with studies consistently showing increased bioactivity and improved stability as key outcomes作者：JE Aguilar-Toalá·2022·被引用次数：136—Studies have demonstrated thatencapsulation of bioactive peptides increases their bioactivity, improves their stability, sensory properties, increases ....
Peptides, by their nature, are susceptible to degradation in various environments作者：L Haines-Butterick·2007·被引用次数：767—A peptide-based hydrogelation strategy has been developed that allowshomogenous encapsulationand subsequent delivery of C3H10t1/2 mesenchymal stem cells.. This vulnerability stems from their susceptibility to enzymatic breakdown (like trypsin hydrolysis), pH changes, and oxidationPeptide-directed encapsulation of inorganic nanoparticles .... Encapsulation provides a physical barrier that shields the peptide from these denaturing factors.1天前—...encapsulationwithin nanostructured carriers can substantially improvepeptidestability and prolong systemic exposure. Nanocarrier systems ... This protection is vital for therapeutic peptides, ensuring they reach their target sites intact and active, and for functional peptides in food or cosmetic applications, where their efficacy can be compromised during processing, storage, or consumption.Controlling hydrogelation kinetics by peptide design for ... The development of advanced encapsulation techniques, such as those utilizing liposomes, nanoparticles (LNPs), and spray-drying, offers tailored solutions for diverse peptide types and applications.
A variety of methods are employed for peptide encapsulation, each offering distinct advantages. Spray-drying, for instance, is a widely used technique for stabilizing functional ingredients and maintaining their activity. Electrospinning, another method, allows for the creation of fibrous matrices that can entrap bioactive peptides. For more targeted delivery, nanocarrier systems like liposomes and polymer nanoparticles are increasingly utilized. These systems can be engineered to control the release rate and site of peptide deliveryEncapsulation of Bioactive Peptides by Spray-Drying and ....
The choice of encapsulating material is equally crucial.Galloyl Dialkyl Lipids Drive Encapsulation of Peptides into ... Proteins, polysaccharides, and lipids are common carrier systems used in food peptide encapsulation. For instance, galloyl (GA)-functionalized lipids have demonstrated efficacy in encapsulating peptides via hydrogen bonding, forming lipid nanoparticles (LNPs). Peptide-based polyelectrolyte complexes, formed by tuning hydrophobicity and charge density through peptide design, offer another versatile platform for encapsulating molecules with varying polarities. Adaptive peptide dispersions also enable efficient encapsulation and retention of payloads through drying-induced processes.
The primary goal of peptide encapsulation is to enhance the performance of peptidesControlling hydrogelation kinetics by peptide design for .... This includes:
* Improved Stability: Protecting peptides from enzymatic degradation, temperature fluctuations, and chemical reactions.
* Enhanced Bioactivity: Ensuring that a higher proportion of the peptide remains active and available to exert its intended biological effect.
* Controlled Release: Designing systems that release peptides at a specific time or location, optimizing their therapeutic or functional impact.
* Masking Sensory Properties: For peptides with undesirable tastes or odors, encapsulation can mask these attributes, improving palatability in food products or comfort in other applications.
* Facilitated Delivery: Enabling peptides that are poorly absorbed orally to be delivered effectively, such as through oral medications or targeted delivery systems.
Encapsulated peptides find applications across various industries. In pharmaceuticals, they are used for drug delivery, improving the efficacy and reducing the side effects of peptide-based therapies. In the food industry, encapsulated bioactive peptides can be incorporated into functional foods to provide health benefits, such as antimicrobial activity or improved nutritional value. Research also explores their use in cosmetics for targeted skin treatments.
The field of peptide encapsulation is continuously evolving, with ongoing research focusing on developing novel materials and techniques. Innovations include creating more sophisticated nanocarrier systems that offer precise control over peptide release and targeting. The exploration of peptide-based self-assembly for encapsulation is also a promising area, allowing for the creation of biocompatible and biodegradable delivery systems.作者：X Zhang·2022·被引用次数：37—We provide a comprehensive update on the application of versatile delivery systems for embedding bioactivepeptides, including liposomes, polymer nanoparticles ... As our understanding of peptide behavior and interaction with different matrices deepens, peptide encapsulation will undoubtedly play an even more significant role in unlocking the full potential of these versatile biomolecules.
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