PolysaccharideKrestin Polysaccharide peptide (PSP) is a complex biomolecule primarily derived from the edible mushroom *Coriolus versicolor*, also known as Turkey Tail. This protein-bound polysaccharide has garnered significant attention for its potential health benefits, particularly as a biological response modifier.作者：SH Hantoko·2016—Dapat disimpulkan bahwaPsPGanoderma lucidum tidak mempengaruhi jumlah leukosit pada tikus. English Abstract.Polysaccharide Peptide(PsP) is ... Research indicates that PSP possesses immunomodulatory properties, capable of influencing the body's immune systempolysaccharide peptides (PSP): uses & side-effects. Its extraction from *Coriolus versicolor* and other fungi like *Ganoderma lucidum* has led to its exploration in various therapeutic applications, often used as an adjunct therapy to support conventional treatments.
The primary source of polysaccharide peptide is the mycelia of *Coriolus versicolor*.作者：SL Chan·2006·被引用次数：54—Polysaccharide peptide(PSP), isolated from Coriolus versicolor COV-1, has been shown to restore the immunological effects against cyclophosphamide-induced ... This fungus, a common inhabitant of decaying hardwood, has a long history of use in traditional medicine, especially in East Asia.A method for producing polysaccharide peptide (PSP) PSP is a glycopeptide, meaning it is composed of both polysaccharide (complex carbohydrate) and peptide (short chain of amino acids) componentsPolysaccharide Peptide Extract From Coriolus versicolor .... This unique structure is believed to be responsible for its biological activity.Polysaccharide Peptide While *Coriolus versicolor* is the most well-known source, similar compounds, sometimes referred to as Polysaccharide Peptide (PsP), have also been identified in other medicinal mushrooms like *Ganoderma lucidum*. The precise composition and efficacy can vary depending on the extraction method and the specific fungal strain used作者：T Heriansyah·2019—Polysaccharide Peptide(PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum]..
The research into PSP highlights several promising areas of application, with a strong focus on immune support and its role in cancer therapy.
* Immunomodulation: One of the most extensively studied aspects of PSP is its ability to modulate the immune system. Studies suggest that PSP can help restore immune function, particularly in cases of immunosuppression induced by chemotherapy or other factors. It is believed to activate various immune cells, thereby enhancing the body's natural defense mechanisms.作者：T Heriansyah·2019—Polysaccharide Peptide(PsP) Ganoderma lucidum: A Potential Inducer For Vascular Repair In Type 2 Diabetes Mellitus Model [Corrigendum].
* Adjunct Cancer Therapy: PSP has been widely used in some regions as an adjunct therapy for cancer patients undergoing chemotherapy or radiation. Its potential to mitigate side effects and support immune recovery during these treatments is a significant area of research.作者：JHK Yeung·2011·被引用次数：18—Polysaccharide peptide(PSP), isolated from COV-1 strain of Coriolus versicolor, is commonly used as an adjunct in cancer chemotherapy in ... Some studies have explored its direct anticancer mechanisms, including inhibiting the proliferation of certain cancer cells, though it is generally not considered a standalone cancer treatment.
* Other Potential Applications: Beyond its immunomodulatory and anticancer effects, research has also explored PSP's potential in addressing other health concerns.capsule contains 250 mg ofPolysaccharide Peptide, which it equal to 180 mg β-1,3/1,6-D-Glucan. β-1,3/1,6-D-Glucan is an immunomodulator that modulates immune ... These include its anti-atherosclerotic properties, where it may help in attenuating hardening of the arteries, and its potential role in vascular repair, particularly in models of type 2 diabetes. It has also been investigated for its effects on conditions like hepatitis, hyperlipidemia, and chronic bronchitis.
It is important to distinguish PSP from Polysaccharide Krestin (PSK), another well-researched compound derived from *Coriolus versicolor*. While both are complex polysaccharides from the same mushroom, they are distinct molecules with potentially different therapeutic profiles and mechanisms of action. PSK has also been widely used in cancer therapy, particularly in Japan, and its efficacy has been supported by numerous clinical trials. Understanding the differences and similarities between PSP and PSK is crucial for researchers and consumers alike.
PSP is generally considered to have low cytotoxicity and a favorable safety profile, with minimal reported side effects in clinical use. However, as with any supplement or therapeutic agent, it is advisable to consult with a healthcare professional before incorporating PSP into one's regimen, especially for individuals with pre-existing medical conditions or those undergoing conventional medical treatments. The quality and standardization of PSP products can also vary, making it important to source from reputable manufacturers. Further research continues to explore the full spectrum of PSP's benefits and its optimal use in various health contexts.
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